GE type 1 silicone will hold an aquarium together just fine. The 1600 gallon & 560 gallon reef glass aquariums I built at my original shop location was held together with it. I have built many aquariums using this brand - very good stuff. It is important to have vary clean and straight mating edges when siliconing tanks together otherwise problems (leaks) can happen. Use a razor blad and white distilled vinegar to clean all the surfaces to be matted together. Use plain, dull (not shiny) news paper as a rag to wipe the surfaces off with - no rags or paper towels. The expensive silicone sold at the local pet shop is made by Dap, Dow or GE and is the same product found in the hardware store but packaged for aquarium use. Your paying a bunch of extra money for packaging.
Using silicone with acrylic is not the best option. If an acrylic panel is being siliconed into a glass aquarium, the silicone will not adhere to the acrylic very well. If there is no pressure being put on the acrylic baffle it should be fine but if the baffle is holding back a deep sand bed, the weight and pressure of the sand may cause the weak bond between the silicone and the acrylic to fail.
Using all glass baffles in a glass aquarium is a better option.
Joel