I think that there are multiple factors that can influence what is the best way to deliver water to a protein skimmer. Note that what I just said was what is the best way to deliver water to a protein skimmer, not what is the best way to remove nutrients from your aquarium or what will make the best use of your protein skimmer.
If this subject was as simple as, "what is the best way to get water into my protein skimmer to allow the protein skimmer to have the maximum benefit to my aquariums water?" the the answer would be, water that has been surface skimmed straight out of the aquarium and drained directly into the skimmer...period!
It is an absolute fact that the raw surface water is the most pollution concentrated portion of aquarium water in all aquariums. Draining water into a sump and then pumping it back into a skimmer decreases the concentration of the surface pollutants getting into the skimmer. Even if the protein skimmer feed pump is located in the first chamber of the sump that water from the aquarium is drained into, it still decreases the concentration of surface pollutants getting to the skimmer. When surface water is churned or disturbed, these pollutants return to the surface very quickly. A pump sitting on the bottom of a sump is going to miss a fair amount of them.
Now, that being said, this is not to say that other methods of water delivery to a protein skimmer are wrong. It's more a case of good, better and best.
There are many circumstances (more than room here will allow for) that will determine if this type of water delivery to your protein skimmer is the right thing to do. The immediate things that come to my mind are;
Recirculation type skimmers are probably the only type of skimmer where this is an option, perhaps old school counter current style with an air stone could too.
Can your skimmer handle that amount of water flow (GPH)?
Is this water volume (GPH) adequate for your size aquarium? Is it to slow (not enough GPH) Is it to fast - to short of dwell time?
Et Cetera.....
I'm certain that there are many more factors that will determine if this can or should be done on ones aquarium / protein skimmer. But I will say that if it is an option to directly feed your protein skimmer right out of the aquarium VIA a surface skimming over flow, this is the best option. Remember that nutrient export / removal is the # 1 priority of our water management systems. Directly feeding the most pollution concentrated water to your protein skimmer and allowing it to remove it before the water enters the next stage of filtration really decreases the load on the entire system. The more quickly & efficiently waste is remove from out water, the better the quality of our water and the longer the duration it will stay that way. These are not opinions, these are facts.
For what it's worth, I have the exact Euro Reef RC 500 protein skimmer that Tim has. I feed it directly from my tank VIA a surface skimmer box. Since doing so, the concentration of waste and the rate I collect it from the aquarium is noticeably greater than it was when it was fed by a pump located in my sump. In my situation, I do see an improvement in performance.
Joel