1. Have to be moved to the fuge
2. I would think you have less chance of creating a large amonnia spike by moving it in increments
3. Have to be moved to the fuge
4. Gains would be that, in theory, you would have a cleaner tank. But if you still have the same materials in the same system, would it be any different? Another gain would be that you could crank up the powerheads without the sand blowing around. Several losses are the "look" of a reef tank, no wrasses that sleep in sand, and no snails like nassarius or fighting conchs in the display.